A Simple, Sensitive and Accurate Reversed Phase High Performance Liquid Chromatographic (RP HPLC) method for analysis of Drospirenone (DROSP) and Ethinyl Estradiol (ETE) drugs in tablet dosage form. Isocratic elution at a flow rate of 1.0ml/min was employed on a symmetry C18 (150x4.6mm, 5μm in particle size) at ambient temperature. The mobile phase consisted of Acetonitrile: Water (70:30). The UV detection of Wave length was 210 nm and 20μl sample was injected. The retention time for DROS was 2.78 min and ETE was 2.33 min. The % Recovery were found to be 99.28%-102% for DROSP and 99.33% - 98.64% for ETE. The proposed method is validated for Linearity, Accuracy and Precision, Limit of Detection (LOD) and Limit of Quantification (LOQ) as per the guidelines ofInternationational Conference on Harmonization (ICH).
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